Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

Abstract Background Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was investigate quantitative SPECT imaging uninfected nonunion compare hypertrophic and non-hypertrophic using volume-based parameters. Methods We evaluated 23 patients with who underwent acquisition 3 h after an injection 99m Tc-hydroxymethylene diphosphonate or Tc-methylene from April 2014 November 2019. reconstructed the acquired data performed voxel-based analysis GI-BONE software. Quantitative parameters, maximum SUV (SUV max ), peak mean ) in high low areas were compared between nonunion. contralateral limb as control, ratios parameters calculated. Results values for (high area/low area, respectively), control ratio (12.13 ± 4.95/6.44 4.71), (11.65 4.58/6.45 4.64), (11.94 5.03/6.28 4.95) higher than those (7.82 4.76/3.41 2.09 ( p = 0.065/0.12), 7.56 4.51/3.61 2.23 0.065/0.22), 7.59 5.18/3.05 1.91 0.076/0.23)). Conclusions , obtained images can quantitatively biological activity nonunions may be effective evaluation method treatment decisions, especially necessity autologous grafting.